Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation
نویسندگان
چکیده
منابع مشابه
The Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease
Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected c...
متن کاملPositive tissue transglutaminase antibodies with negative endomysial antibodies: low rate of celiac disease.
BACKGROUND Screening for celiac disease is based on the sequential evaluation of serologic tests and intestinal biopsy; an optimal screening protocol is still under investigation. The screening policy of one of the main healthcare providers in Israel (Maccabi) consists of measuring total immunoglobulin A and tissue transglutaminase IgA antibodies and confirming positive results by endomysial an...
متن کاملThe Changing Clinical Presentation of Celiac Disease
The incidence, the age at presentation and the features of celiac disease (CD) in children have changed considerably over the past 20 years. CD is now believed to be the most common genetically predetermined condition in humans with a prevalence of 1%. Only approximately one third of the patients presents with diarrhea while one third is diagnosed upon screening, and one fifth presents with non...
متن کاملComparison of assays for anti-endomysial and anti-transglutaminase antibodies for diagnosis of pediatric celiac disease.
BACKGROUND Anti-endomysial antibodies are sensitive and specific markers for celiac disease. This antibody has recently been identified as an antibody to tissue transglutaminase, an enzyme that cross-links and stabilizes extracellular matrix proteins. OBJECTIVES To evaluate the clinical usefulness of an enzyme-linked immunoassay for anti-transglutaminase antibodies, and to compare the results...
متن کاملthe clinical presentation of celiac disease: experiences from northeastern iran
background this study aimed to explore demographic characteristics and clinical presentations of celiac disease (cd) in northeastern iran. methods this was a cross-sectional retrospective study of 193 adults with cd who presented to mashhad university gastroenterology clinic between 2008 and 2013. patient data that included mode of presentation and the presence of any concomitant illnesses were...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2012
ISSN: 1007-9327
DOI: 10.3748/wjg.v18.i20.2511